DespairWear is the t-shirt line of Despair Inc., a company known for its particularly pessimistic brand of humor. If you’re looking for humor, slogan, or pop culture tees, this may be one of the best places to go.

Go Ape Shirts is a one-man operation, and an impressive one at that. This company features a large catalog filled with interesting designs. And yes, everything’s printed on American Apparel.

Frank & Jan’s biting humor and skillful use of vintage art and photos make for a unique line of tees. If you like witty shirts with a punch, you might want to check these guys out.

Powerup Apparel is a new brand from South Dakota, USA. There aren’t many shirts yet, but it shows a lot of promise.

Medicore Clothing is a US brand based on pop culture from the 80’s and 90’s. The designs are unique, clever, and are sure to bring a surge of nostalgia.

Crispy Tees brings original concepts to the copy-your-neighbor world of humor t-shirts. The satirical pop culture references are genuinely clever, and more importantly, funny.