Freegums is a one-man label run by Alvaro Ilizarbe out of Miami. It labels itself not as a fashion or streetwear brand, but as an “artistic label.” The designs are fun and quirky, but don’t have one particular style as a whole.

You know American Apparel for their comfy blank shirts and progressive ideas, now check out their impressive line of printed graphic tees!

Flying Mouse 365 is the brainchild of Flying Mouse (Chow Hon Lam), a Malaysian designer who has found considerable success in the Threadless contest. Recently, he threw open the doors to his own tee store, where you can preorder seven new designs each week.

Made With Awesome was born when two Threadless veterans got together to start their own line of tees and prints. And yes, the shirts are indeed made of awesome.

Lowdtown F&F is a young New Jersey indie brand which got its start in 2009. Their shirts make use of bold vector design, strange characters, and bright colors.

Johnny Cupcakes is the independent US brand that has become the poster boy for indie tee company success. It is known for its trademark cupcake-and-crossbones logo and its limited edition shirts.